产品货号：
Z10401
中文名称：
ACTN4抗体
英文名称：
Anti-ACTN4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ACTN4 Antibody |
| 指标别名 | ACTININ 4;actinin;alpha 4;ACTN4;Alpha actinin 4;F actin cross linking protein;FSGS;FSGS1;Non muscle alpha actinin 4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | ACTN4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Alpha Actinin 4 recombinant protein (Position:E561-V661).Human Alpha Actinin 4 shares 99% and 98% amino acid (aa) sequence identity with mouse and rat Alpha Actinin 4,respectively. |
| 实际分子量 | 105KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins,including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells,the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions,where it is involved in binding actin to the membrane.In contrast,skeletal,cardiac,and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies,where they help anchor the myofibrillar actin filaments.This ACTN4 gene encodes a nonmuscle,alpha actinin isoform which is concentrated in the cytoplasm,and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. |
| Uniprot ID | O43707 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | actinin alpha 4 |
| 蛋白名全称 | Alpha-actinin-4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow Cytometry (FCM) 1～3μg/1×106 cells Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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